Impact of Structural Alerts on Drug Discovery: A Comprehensive Analysis of Marketed Drugs
- Re-examining the role of structural alerts by analyzing over 1,000 orally administered marketed drugs to understand how frequently alerts occur in clinically successful compounds
- Disentangling correlation from causation by evaluating relationships between structural alerts, reactive metabolite formation, DILI potential, daily dose, and therapeutic area
- Informing smarter de-risking strategies by showing where structural alerts meaningfully contribute to risk assessment and where over-reliance may unnecessarily limit innovation