OASIS Consortium: Using Phenotypic Liver Models to Improve Human- Relevant Toxicity Translation

• Leverage OASIS Consortium and liver-focused cell painting data to link complex in vitro phenotypes with known human safety outcomes
• Improve confidence in translation by comparing mechanistic in vitro signatures against clinical liver toxicity patterns rather than relying on single endpoints
• Strengthen early safety decisions by positioning high-content liver NAMs as a bridge between discovery screening and human risk understanding

Speakers:

David Rouquie

LifeHub Sophia Lead & Head, Toxicology Data Science

Bayer