David Rouquie
LifeHub Sophia Lead & Head, Toxicology Data Science Bayer
Seminars
Thursday 14th May 2026
OASIS Construction: Using Phenotypic Liver Models to Improve Human- Relevant Toxicity Translation
9:00 am
- Leverage OASIS construction and liver-focused cell painting data to link complex in vitro phenotypes with known human safety outcomes
- Improve confidence in translation by comparing mechanistic in vitro signatures against clinical liver toxicity patterns rather than relying on single endpoints
- Strengthen early safety decisions by positioning high-content liver NAMs as a bridge between discovery screening and human risk understanding
